第六十屆司法節致詞 翁院長、諸位大法官、諸位司法首長、諸位貴賓： 今天是第六十屆司法節，司法院改變以往均以集會慶祝司法節的傳統方式，於中正紀念堂舉辦百年司法活動，展覽司法文物暨司法美展，一方面藉由歷史文物史料及法界前輩口述歷史的時光隧道，讓參觀民眾認識台灣司法的變遷，緬懷司法前輩們的風範並見證司法薪火的傳承。另一方面藉由展出司法同仁的藝術作品，讓參觀民眾了解法律人積極的人生態度與豁達的視野，充分展現司法改革永遠追求創意與革新的精神，實在值得肯定與讚賞。誠蒙翁院長邀請前來參加開幕儀式，深感榮幸，謹代表全國律師公會祝賀此項百年司法活動。 台南地方法院舊址，是台灣現存日治時代早期唯一的法院大型建築，有全台日治時代最精緻的門廊‧最華麗的門廳及最莊嚴的圓頂，圓頂內部的特殊木料，在台灣找不到任何相同的例子，內政部指定為二級古蹟，並經司法院規劃為司法博物館預定地，實在名符其實。回憶三十四年前我很榮幸在台南地方法院擔任法官，可惜兩年半後因個人生涯規劃毅然辭職轉任律師，如果時光可以倒流，我真不知道是否會做同樣的決擇。 最後，敬祝百年司法活動圓滿成功，諸位貴賓健康快樂。

CURRICULUM VITAE Jack Meng-Fen Su, M.D., M.S. Texas Children’s Cancer Center, Baylor College of Medicine 6701 Fannin Street, CC 1510 Houston, Texas 77030 Phone: 832-822-4306 Fax: 832-825-1503 E-mail: jmsu@txch.org (Updated December 2013) I. GENERAL BIOGRAPHICAL INFORMATION A. Personal Name: Jack Meng-Fen Su Date of Birth: March 28, 1968 Place of Birth: Ping Tung, Taiwan Citizenship: USA B. Education Undergraduate Education Stanford University, Palo Alto, California. Bachelor of Science, Chemistry – Graduated with Distinction, 1990 Medical/Graduate Education University of California, San Francisco, School of Medicine, California. M.D., 1994 Master of Science, Clinical Investigation. Clinical Scientist Training Program, Baylor College of Medicine, Houston, Texas, 2003-2007. Postgraduate Training Pediatric Residency, University of California, San Francisco, California, 1994-1997. Pediatric Hematology-Oncology Fellowship, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, Texas, 1997-2001. Fellowship, Pediatric Oncology Clinical Research Program, (National Cancer Institute) Texas Children’s Cancer Center, Baylor College of Medicine, Houston, Texas, 2002-2006. C. Academic Appointment 2005-present Assistant Professor Department of Pediatrics – Division of Hematology-Oncology Baylor College of Medicine 2001-2005 Instructor Department of Pediatrics – Division of Hematology-Oncology Baylor College of Medicine D. Other Advanced Training/Experience July 2001 American Association of Cancer Research, Molecular Biology in Clinical Oncology Workshop August 2005 American Society of Clinical Oncology, Methods in Clinical Cancer Research Workshop July 2007 Visiting Fellowship, Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland E. Other Information Honors and Awards 1988-1990 Eastman Kodak Scholarship in Chemistry 1989 Phi Beta Kappa, Stanford University, Palo Alto, California 1990 Outstanding Student of the Year, Department of Chemistry, Stanford University, Palo Alto, California 1993 UCSF Class of 1997 Orientation Speaker, “On Becoming a Physician,” University of California, San Francisco 2000-2001 American Society of Clinical Oncology Young Investigator Award 2000-2001 Association for Research of Childhood Cancer, Inc., Basic Science Research Grant 2001-2002 New Project Development Award, Child Health Research Center, Baylor College of Medicine 2001-2003 Pediatric Brain Tumor Foundation of the United States, Clinical Fellowship in Pediatric Brain Tumor Research 2002-2006 Pediatric Oncology Clinical Research Training Fellowship, National Institute of Health 2006-2007 CureSearch Research Fellowship Award, Children’s Oncology Group 2006-2008 Childhood Brain Tumor Foundation Research Grant 2006-2010 K23 Career Development Grant National Cancer Institute 2008-2009 Hyundai Pediatric Cancer Research Scholar, Hope on Wheels Program 2011-2013 Cookies for Kids’ Cancer Research Grant 2011-2013 St. Baldrick’s Foundation Consortium Grant Board Eligibility/Certification American Board of Pediatrics, 1997 (re-certified in 2004 and 2011) American Board of Pediatrics, subspecialty in Pediatric Hematology/Oncology, 2000 (re-certified in 2007) Medical Licensure 1996-present California Licensure of Physicians and Surgeons 2001-present Texas Licensure of Physicians II. RESEARCH INFORMATION A. Research Support St. Baldrick’s Foundation Consortium Grant (PI: Jack M Su) 7/1/2011-6/30/2014 $300,000 “Comprehensive Studies of Pediatric CNS Tumors Through a Texas Consortium” Specific aims of the project: 1) Collect appropriate biologic samples from children with brain tumors and perform state-of-the-art genomic studies to understand the mechanisms of tumor development and to identify unique molecular targets with diagnostic and therapeutic significance; 2) Develop biologically and clinically relevant animal models of pediatric brain tumors to enable pre-clinical testing of novel therapies; 3) Perform epidemiologic (case-control and triad) studies to explore unidentified environmental and/or genetic risk factors for childhood brain tumors. Cookies for Kids Cancer Research Grant (PI: Jack M Su) 4/1/2011-4/1/2013 $100,000 “Pre-Clinical and Clinical Studies of ABT-888, an Oral Poly(ADP-Ribose) Polymerase (PARP) Inhibitor, for Enhancing Radiation and Chemotherapy Efficacy in Children with Newly Diagnosed High-Grade or Brainstem Gliomas” Specific Aims of the project: 1) Perform pre-clinical studies of ABT-888 and radiation enhancement in pediatric GBM xenograft models, 2) Study the mechanism(s) of resistance for PARP inhibition in pediatric GBM and diffuse intrinsic pontine (DIPG) models, and 3) Initiate a phase I/II study of ABT-888 and radiation, followed by maintenance ABT-888 and temozolomide, in children with newly diagnosed high-grade gliomas or DIPG. NIH-NCI K-23 5K23CA113721 Career Development Award (PI: Jack M Su) 9/01/2006-8/31/2010 $450,000 “Study of Valproic Acid in Pediatric Brain Tumors” Major Goals of Project: 1) To complete a limited Phase I trial to study the toxicities and pharmacokinetics of chronic VPA administration in children with recurrent solid tumors, including brain tumors, 2) To correlate free and total VPA concentrations with degrees of histone acetylation in peripheral blood monocytes from patients accrued in Specific Aim 1, and define the optimal serum VPA concentration to target for the subsequent phase 2 clinical trial, 3) to initiate a national cooperative group Phase 2 clinical trial of VPA in children with recurrent/refractory MB or malignant gliomas, and to correlate histone hyper-acetylation and serum and CSF VPA concentrations with clinical response, and 4) To study VPA’s potential as a radiation sensitizer for pediatric CNS tumors and a neuro-protectors in animal models, with a plan for a future phase 1 clinical trial to study the feasibility and toxicities of administering VPA with up-front radiation in children with CNS tumors. Childhood Brain Tumor Foundation Research Grant (PI: Jack M. Su) 7/1/2006-6/30/2008 $200,000 “A Pre-Clinical Study of an Oral Poly(ADP-ribose) Polymerase Inhibitor to Enhance Temozolomide and Radiation Sensitivity of Pediatric Glioblastoma Multiforme and Medulloblastoma Intracranial Xenografts in Mice” Children’s Oncology Group CureSearch Research Fellowship Award (PI: Jack M. Su) 7/1/2006-6/30/2007 $100,000 “A Pre-Clinical Study of an Oral Poly(ADP-ribose) Polymerase Inhibitor and Temozolomide in Mice Bearing Orthotopic Intracranial Xenografts of Pediatric Glioblastoma Multiforme or Medulloblastomas” Fellowship Trainee, NIH-NCI K12 CA90433-01A1 Pediatric Oncology Clinical Research Training Program (PI: D.G. Poplack) 07/01/2002-06/30/2006 $517,418 Pediatric Brain Tumor Foundation of the United States Clinical Fellowship in Pediatric Brain Tumor Research (PI: Jack M. Su) 10/01/2001-09/30/2003 $100,000 “Studying the Molecular Pathogenesis and Cellular Origin of Medulloblastomas in Patched-Deficient Mice” New Project Development Award Child Health Research Center, Baylor College of Medicine (PI: Jack M. Su) 12/01/2001-11/30/2002 $24,876 “Studying the Molecular Pathogenesis and Cellular Origin of Medulloblastomas in Patched-Deficient Mice” American Society of Clinical Oncology Young Investigator Award (PI: Jack M. Su) 7/01/2000-6/30/2001 $35,000 “Molecular Pathogenesis of Medulloblastoma” Association for Research of Childhood Cancer Grant for Basic Science Research (PI: Jack M. Su) 7/01/2000-6/30/2001 $30,000 “Microarray Analysis of Medulloblastomas in Patched-Deficient Mice” B. National Scientific Participation 1. Clinical Study Committee Study Chair, ADVL0419, Phase I Study of Valproic Acid in Children with Recurrent/Progressive Solid Tumors, Including CNS Tumors, Children’s Oncology Group, Phase I Consortium; study completed in June 2008. Study Chair, A Phase 1 Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase, and Temozolomide in Children with Recurrent/Progressive CNS Tumors (PBTC-027; NCT00946335), Pediatric Brain Tumor Consortium; study competed July 2012. Study Co-Chair, A Phase 2 Study of Valproic Acid and Radiation, Followed by Maintenance Valproic Acid and Bevacizumab in Children with Newly Diagnosed High-Grade Gliomas or Brainstem Gliomas (NCT00879437), Texas-Oklahoma Pediatric Neuro-Oncology Consortium. Study Chair, A Phase I/II Study of Suberoylanilide Hydroxamic Acid (SAHA; Vorinostat) and Local Irradiation, Followed by Maintenance SAHA in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ACNS0927; NCT01189266), Children’s Oncology Group. Study Co-Chair, A Phase I/II Study of ABT-888, an Oral Poly( ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Gliomas (PBTC33, NCT01514201). Co-investigator, Phase I Trial of the Administration of HER2 Chimeric Antigen Receptor Expressing CMV-Specific Cytotoxic T Cells in Children with Newly Diagnosed Glioblastoma (GBM) and Recurrent Medulloblastoma (MB) (PBTC040, in development) Central Nervous System Tumor Disease Committee, Children’s Oncology Group, October 2009 through present. Scientific Committee, Pediatric Brain Tumor Consortium, October 2011 through present Co-Chair, New Agent and Pharmacology Committee, Pediatric Brain Tumor Consortium, October 2011 through present. 2. Professional Societies Children’s Oncology Group Pediatric Brain Tumor Consortium American Association of Cancer Research Society of Neuro-Oncology American Society of Clinical Oncology 3. Invited Lectures and Presentation September 2003, invited speaker for the Pediatric Brain Tumor Foundation of United States Annual Meeting, Ashville, North Carolina “Inhibition of histone deacetylase and poly(ADP-ribose) polymerase as novel therapies in pediatric CNS tumors.” Diagnosis and Therapeutic Discovery in Neuro-Oncology Research Symposium, Baylor College of Medicine, Houston, Texas, October 13, 2006. “Inhibition of poly(ADP-ribose) polymerase as a novel treatment strategy for pediatric CNS tumors.” The International Symposium of Pediatric-Oncology, Taipei, Taiwan, October 21-22, 2007. Combination of a poly(ADP-ribose) polymerase inhibitor and temozolomide suppresses growth of pediatric glioblastoma multiforme and medulloblastoma in orthotopic mouse xenografts. The Thirteenth International Symposium on Pediatric Neuro-Oncology, Chicago, Illinois, June 29 to July 2, 2008. Pediatric High-Grade and Brainstem Gliomas: A Review of What We Have Done in the Past, and a Brainstorm for New Directions in the Future. Cook Children’s Hospital 2012 Pediatric Brain Tumor Symposium, November 2-3, 2012. Journal Reviewer Child’s Nervous System C. Publications 1. Full Papers a. published in peer review journals Li XN, Parikh S, Shu Q, Jung HL, Chow CW, Perlaky L, Leung HE, Su JM, Blaney SM, Lau CC. Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res 2004, 10(3): 1150-9. PMID: 14871995 Su JM, Perlaky L, Li XN, Leung HC, Antalffy BA, Armstrong D, Lau CC. Comparison of ethanol versus formalin fixation on preservation of histology and RNA in laser capture microdissected brain tissues. Brain Pathol 2004; 14(2): 175-82. PMID: 15193030 Wong KK, Cheng YM, Tsang YTM, Perlaky L, Su JM, Adesina A, Armstrong DL, Bhattacharjee MB, Dauser R, Blaney SM, Chintagumpala M, Lau CC. Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. Cancer Res 2005; 65(1): 76-84. PMID: 15665281 Li XN, Shu Q, Su JM, Perlaky L, Blaney SM, Lau CC. Valproic acid induces growth arrest, apoptosis, and senescence by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. Mol Cancer Ther 2005; 4(12): 1912-22. PMID: 16373706 Shu Q, Su JM, Antalffy BA, Adesina A, Ou CN, Pietsch T, Blaney SM, Lau CC, Li XN. Valproic acid extends survival of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Clin Cancer Res 2006; 12(15): 4687-94. PMID: 16899619 Wong KK, Tsang YTM, Chang YM, Di Francesco AM, Meco D, Riccardi R, Perlaky L, Su JM, Adesina A, Bhattacharjee MB, Dauser R, Blaney SM, Chintagumpala M, and Lau CC. Genome-wide allelic imbalance analysis of pediatric glioma by single nucleotide polymorphic allele (SNP) array. Cancer Res 2006; 66(23): 11172-8. PMID: 17145861 Li XN, Shu Q, Su JM, Adesina A, Wong KK, Perlaky L, Antalffy BA, Blaney SM, Lau CC. Differential expression of survivin splice isoforms in medulloblastomas. Neuropathol Appl Neurobiol 2007; 33(1): 67-76. PMID: 17239009 De Bortoli M, Castellino RC, Skapura DG, Shen JJ, Su JM, Russell HV, Hicks MJ, Man TK, Kim JYH. Patched heterozygous mouse rhabdomyosarcomas overexpress secreted phosphoprotein 1 and matrix metalloproteinases. Eur J Cancer 2007; 43: 1308-17. PMID: 17467979 Takei H, Dauser R, Su JM, Chintagumpala M, Bhattacharjee MB, Jones J, Adesina AM. Anaplastic ganglioglioma arising from a Lhermitte-Duclos-like lesion. Case report. J Neurosurg 2007; 107(2 Suppl): 137-42. PMID: 18459885 Shu Q, Wong KK, Su JM, Adesina AM, Yu LT, Tsai-Lee Y, Antalffy BA, Perlaky L, Dauser R, Chintagumpala M, Blaney SM, Lau CC, Li XN. Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells 2008; 26(6): 1414-24. PMID: 18403755 Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P. Pituitary and systemic autoimmunity in a case of intrasellar germinoma. Pituitary 2011; 14(4): 388-94. Epub 2009 May 26. PMID: 19466616 Muscal JA, Jones JY, Paulino AC, Bertuch AA, Su JM, Woo SY, Mahoney DH Jr, Chintagumpala M. Changes mimicking new leptomeningeal disease after intensity-modulated radiotherapy for medulloblastoma. Int J Radiat Oncol Biol Phys 2009; 73(1): 214-21. PMID: 18485616 Muscal JA, Thompson PA, Giranda VL, Dayton BD, Bauch J, Horton T, McGuffey L, Nuchtern JG, Dauser RC, Gibson BW, Blaney SM, Su JM. Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates. Cancer Chemother Pharmacol 2010; 65(3): 419-25. PMID: 19526240 Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM, Su JM, Perlaky L, Dauser R, Chintagumpala M, Lau CC, Blaney SM, Rao PH, Leung HC, Li XN. A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. Neuro Oncol 2010; 78(5): 1445-50. PMID: 20511191 Paulino AC, Lobo M, Teh BS, Okcu MF, South M, Butler EB, Su JM, Chintagumpala M. Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma. Int J Radiat Oncol Biol Phys 2010; 78(5): 1445-50. PMID: 20231075 Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina AM, Perlaky L, Hurwitz MY, Idamakanti N, Police SR, Hallenbeck PL, Blaney, SM, Chintagumpala M, Hurwitz RL, Li XN. A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models, Neuro Oncol 2011; 13(1): 14-27. PMID: 21075780 Paulino AC, Mazloom A, Teh BS, South M, Okcu MF, Su JM, Butler EB, Chintagumpala M. Local control after craniospinal irradiation, intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma, Cancer 2011; 117(3): 635-41. PMID: 20845476 Su JM, Li XN, Thompson P, Ou CN, Russell HV, Ingle AM, Lau CC, Adamson PC, Blaney SM. Phase 1 study of valproic acid in pediatric patients with refractory solid or tumors: a Children’s Oncology Group report, Clin Cancer Res 2011; 17(3): 589-97. PMID: 21115653 Cheung HC, Yatsenko SA, Kadapakkam M, Legay H, Su J, Lupski JR, Plon SE. Constitutional tandem duplication of the 9q34 that truncates EHMT1 in a child with ganglioglioma. Ped Blood Can 2012, 58(5): 801-5. Epub 2011 Jun 16. PMID: 21681934 Zhao X, Liu Z, Yu Li, Zhang Y, Baxter PA, Voicu H, Gurusiddappa S, Luan J, Su JM, Leung HE, Li XN. Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma. Neuro-Oncol 2012; 14(5):574-83. Epub 2012 Mar 29. Seto ES, Proud M, Adesina AM, Su JM, Muscal E. Clinical reasoning: an 8-year-old girl with multifocal brain lesions and cerebral edema. Neurology 2012; 78(19): e117-21. Hwang SW, Su JM, Jea A. Diagnosis and management of brain and spinal cord tumors in the neonate. Semin Fetal Neonatal Med 2012; 17(4): 202-6. Epub 2012 Mar 30. Blaney SM, Tagen M, Onar-Thomas A, Berg SL, Gururangan S, Scorsone K, Su J, Goldman S, Kieran MW, Kun L, Boyett J, Stewart C. A phase-1 pharmacokinetic optimal dosing study of intraventricular topotecan for children with neoplastic meningitis: A pediatric brain tumor consortium study. Pediatr Blood Cancer, 2013: 60(4):627-32. Epub 2012 Sep 21. Teo WY, Shen J, Su JM, Yu A, W J, Chow WY, Li XN, Jones J, Dauser R, Whitehead W, Adesina AM, Chintagumpala M, Man TK, Lau CC. Implications of tumor location on subtypes of medulloblastoma, Pediatr Blood Cancer, 2013: 60(9): 1408-10. Epub 2013 March 19. Terashima K, Chow K, Jones J, Ahern C, Eunji J, Ellezam B, Paulino AC, Okcu MF, Su J, Adesina AM, Mahajan A, Dauser R, Whitehead W, Lau CC, Chintagumpala M. Long-term outcome of centrally located low-grade glioma in children. Cancer, 2013: 119(14): 2630-8. Epub 2013 Apr 26. Paulino AC, Mazloom A, Terashima K, Su J, Adesina AM, Okcu MF, Teh BS, Chintagumpala M. Intensity modulated radiotherapy in pediatric low grade glioma. Cancer, 2013: 119(14): 2654-9. Epub 2013 Apr 30. Liu Z, Zhao X, Mao H, Baxter PA, Huang Y, Yu L, Wadhwa L, Su JM, Adesina AM, Perlaky L, Hurwitz MY, Idamakanti N, Police SR, Hallenbeck PL, Hurwitz RL, Lau CC, Chintagumpala M, Blaney SM, Li XN. Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma. Neuro-Oncol, 2013; 15(9): 1173-85. Epub 2013 May 10. Terashima K, Yu A, Chow WY, Hsu WC, Chen P, Wong S, Hung YS, Suzuki T, Nishikawa R, Matsutani M, Nakamura H, Ng HK, Allen JC, Aldape KD, Su JM, Adesina AM, Leung HC, Man TK, Lau CC. Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors. Pediatr Blood Cancer 2013 Nov 19. [Epub ahead of print] Liu Z, Zhao X, Wang Y, Mao H, Huang Y, Kogiso M, Qi L, Baxter PA, Man TK, Adesina AM, Su JM, Picard D, Ho KC, Huang A, Perlaky L, Lau CC, Chintagumpala M, Li XN. A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children. Neuro-Oncology 2014 Jan 26. [Epub ahead of print]. 2. Other Full Papers a. in preparation or submitted for review Su, JM, Thompson P, Adesina AM, Li XN, Kilburn L, Onar A, Kocak M, Chyla B, McKeegan E, Warren KE, Goldman S, Pollack I, Fouladi M, Chen A, Giranda V, Boyett J, Kun L, Blaney SM. A phase I clinical trial of veliparib and temozolomide in children with recurrent central nervous system tumors: a Pediatric Brain Tumor Consortium report, submitted to Neuro-Oncology. Su JM, Adesina AM, Yu LT, Zhao XM, Liu ZG, Liu XS, Dolan ME, Delay SM, Lau CC, Giranda VL, Blaney SM, Li XN. Poly(ADP-ribose) polymerase inhibition by ABT-888 enhances temozolomide efficacy in orthotopic xenograft models of pediatric medulloblastoma and glioblastoma multiforme, submitted to Neuro-Oncology. Teo WY, Elghetany MT, Liu DF, Shen J, Man TZ, Li XN, Chintagumpala M, Su JM, Dauser R, Whitehead W, Adesina AM, Song L, Metelitsa L, Lau CC. CD1d expression predicts survival of pediatric patients with medulloblastoma, submitted to BMC Cancer. Teo WY, Ross J, Bollo R, Seow WT, Tan AM, Kang SG, Li XN, Lau CC, Kim DS, Mohilla CA, Adesina AM, Su JM. Atypical location and clinical behavior of non-teratomatous intracranial germ cell tumors in children younger than 3 years of age. Pediatr Blood Cancer, submitted to J Neurosurgery Pediatrics. Mahajan A, Paulino AC, Jones JY, Ketonen LM, Terashima K, Ater JL, Su JM, Grosshans DR, Adesina AM, Dauser RC, Winberg JS, Chintagumpala M. Cohort comparison of MRI changes in pediatric patients with low grade glioma treated with proton or photon radiotherapy, submitted to Lancet Oncology. 3. Book Chapter Su JM. Pediatric intracranial germ cell tumors. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2009. 4. Abstracts during last three years Liu ZG, Zhao XM, Baxter P, Tao YL, Su JM, Adesina AM, Chintagumpala M, Blaney SM, Xia YF, Li XL. Radiation resistance of orthotopic glioblastoma xenografts is mediated by increasing CD133+ cell fraction, mobilizing G0 cells into G1 phase, and activating self-renewal and mesenchymal genes. Proceedings of 102nd American Association of Cancer Research 2011 Annual Meeting, Orlando, FL, April 2-6, 2011: abstract #570.* Baxter PA, Liu Z, Zhao X, Mao H, Huang Y, Zhang Y, Su JM, Adesina AM, Chintagumpala M, Lau CC, Blaney SM, Li XN. Identification of therapy resistant pediatric brain tumor cells that have extraordinary survival and tumorigenic capabilities: the ultimate seed cells that drives the growth of autopsied tumor cells in mouse brains. Proceedings of 103nd American Association of Cancer Research 2012 Annual Meeting, Chicago, IL, March 31-April 4, 2012: abstract #2364.* Paulino AC, Su JM, Dauser RC, Whitehead W, Teh BS, Chintagumpala M. Feasibility and preliminary results of fractionated full course reirradiation using IMRT in children with anaplastic ependymoma. International Symposium on Pediatric Neuro-Oncology 2012, Toronto, Canada, June 24-27, 2012.* Terashima K, Chow KH, Jones J, Ahern C, Jo E, Ellezam B, Okcu MF, Su JM, Adesina AM, Paulino AC, Dauser RC, Whitehead W, Lau CC, Chintagumpala M. Long-term outcome of centrally located low-grade glioma in children. International Symposium on Pediatric Neuro-Oncology 2012, Toronto, Canada, June 24-27, 2012.* Paulino AC, Terashima K, Su JM, Dauser RC, Okcu MF, Whitehead W, Teh BS, Baxter PA, Chintagumpala M. Impact of Target Volume on Local Control after Intensity Modulated Radiation Therapy (IMRT) for Pediatric Low Grade Glioma. American Society for Radiation Oncology 54th Annual Meeting, Boston, MA, October 28-31, 2012.** Su, JM, Thompson P, Adesina AM, Li XN, Kilburn L, Onar A, Kocak M, Chyla B, McKeegan E, Warren KE, Goldman S, Pollack I, Fouladi M, Chen A, Smith M, Giranda V, Boyett J, Kun L, Blaney SM. A phase I clinical trial of veliparib and temozolomide in children with recurrent central nervous system tumors: a Pediatric Brain Tumor Consortium report. 2013 American Society of Clinical Oncology annual meeting, Chicago, IL, May31-June 4, 2013: abstract 2036 (poster discussion).* Abboud MT, Su JM, Chintagumpala M, The B, New P, Butler B, Paulino AC. Intensity modulated radiation therapy (IMRT) for intracranial germ cell tumors (GCT), abstract submitted for American Society for Radiation Oncology 2013 Meeting. Paulino AC, Narayana A, Chintagumpala M, Su JM, Weltman E. Fractionated reirradiation (50 to 54 Gy) using IMRT for isolated tumor bed recurrence in children with ependymoma, submitted for Congress of the International Society of Pediatric Oncology 2013 Meeting. Qi L, Huang Y, Kogiso M, Mao H, Lindsay H, Baxter PA, Su JM, Perlaky L, Lau CC, Chintagumpala M, Li XN. CD57 defines a novel marker of glioblastoma stem cells that are highly enriched in the invasive subpopulations, submitted for the 105th American Association of Cancer Research 2014 Annual Meeting. Lindsay H, Kogigo M, Qi L, Teo WY, Huang Y, Mao H, Lin F, Baxter PA, Su JM, Terashima T, Perlaky L, Lau CC, Parsons DW, Chintagumpala M, Li XN. Establishment of patient-tumor derived orthotopic xenograft models of metastatic pediatric germinoma, submitted for the 105th American Association of Cancer Research 2014 Annual Meeting. * poster presentation ** oral presentation III. TEACHING INIFORMATIONT A. Didactic Course Work: 1. Courses taught at BCM within the primary department Lectures to medical students and residents during the core pediatrics rotation: “Anemia,” “Abdominal Tumors,” “Pediatric CNS Tumors,” “Thrombocytopenia,” Oncologic Emergencies.” B. Non-Didactic Teaching While at BCM 1. Resident Training Attending Physician on Pediatric Hematology-Oncology Ward, 2001-present. Attending Physician on Pediatric Hematology-Oncology Consult Service, 2001-present. Pediatric Hematology-Oncology Clinic, two days per week. 2. Fellow Education  “Overview of Pediatric CNS Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, June 10, 2005.  “Medulloblastoma Biology and Novel Treatments,” Neuro-Oncology Tumor Board, Texas Children’s Cancer Center, November 17, 2005.  “Review of Infant Medulloblastomas: Treatment and Outcome,” Neuro-Oncology Tumor Board, Texas Children’s Cancer Center, February 2, 2006.  “Pediatric CNS Germ Cell Tumors, “ Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, June 22, 2006.  “Review of Supratentorial PNET,” Neuro-Oncology Tumor Board, Texas Children’s Cancer Center, November 14, 2006.  “Pediatric Glioma and CNS Germ Cell Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, July 14, 2008.  “Pediatric Glioma and CNS Germ Cell Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, July 8, 2009.  “Pediatric Glioma and CNS Germ Cell Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, July 6, 2010.  “Pediatric Glioma and CNS Germ Cell Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, July 6, 2011.  “Pediatric Glioma and CNS Germ Cell Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, July 17, 2012.  “Pediatric Glioma and CNS Germ Cell Tumors,” Fellow’s lecture series, Pediatric Hematology-Oncology, Texas Children’s Cancer Center, July 12, 2013. 3. Neuro-oncology and solid tumor journal club, Texas Children’s Cancer Center: March 2013 through present. 4. Research Fellow Mentoring Research Scholarship Oversight Committee: advisory committee members for Holly Lindsay and Kevin Bielamowicz (second year hematology-oncology fellows) IV. MEDICAL AND SERVICE INFORMATION A. Patient Care Responsibilities at BCM and/or Its Affiliated Institutions 1. Department-wide Attending Physician, Texas Children’s Hospital Consult Physician, Texas Children’s Hospital 2. Section or Specialty Attending Physician, Texas Children’s Cancer Center, Neuro-Oncology Clinic B. Administrative Assignments at BCM 1. Department Texas Children’s Cancer Center, Clinical Research Team Leader, Neuro-Oncology Team, 2009-present Texas Children’s Cancer Center, CNS Tumor Tissue Bank, Tissue Request Review Committee, 2008-present Clinical Protocol Review Committee, Texas Children’s Cancer Center, Baylor College of Medicine, 2003-2011. Data Review Committee, Texas Children’s Cancer Center, Baylor College of Medicine, 2003-2008. 2. College Institutional Review Board for Human Subject Research, Baylor College of Medicine, 2003-2006.

金婚紀念日的告白 2015.11.28 親愛的老婆： 欣逢我們金婚紀念日，原想應該隆重慶祝，藉以稍為彌補當初妳委屈嫁給我的寒酸婚禮！回憶當初蘇家沒有經濟能力為妳舉辦風光婚禮，現在我雖有經濟能力為妳舉辦世紀排場的金婚紀念，但是因為我深深知道金婚紀念對妳而言，已經毫無意義，甚至我想送給妳一份稍為貴重禮物，都被妳堅決婉拒，真是為時已晚，情何以堪！ 民國62年我基於生涯規劃，辭去法官職務轉任律師。7年後因為響往美國的教育環境，懇請妳辭去教職前往美國擔任義務台傭照顧3個孩子10年，讓3個孩子都能完成美國名列前10名大學的學業。現在3個孩子已經成家立業，各擁有令人羨慕的謀生工作，但這些成就畢竟是妳為蘇家所付出犧牲奉獻的痛苦代價！誠如妳經常怨嘆：「我被迫辭去教師職位,含淚帶著三個小孩去美國唸書, 並留在美國照顧他們. 如今孩子大了, 各有自己的天下, 我卻失去了人人羨慕的18%退休金, 如今想起, 後悔莫及, 如果人生能夠重來, 打死不幹, 雖然我現在過著還可以的生活, 但覺得一生最大的遺憾莫過於此.」。尤其101年1月14日總統選舉當天，因為我開車打瞌睡所造成的車禍浩劫，雖然我們很幸運還能從鬼門關走回來，但是妳由於這次車禍所失去的健康，迄今仍然無法回復，而始終耿耿於懷，真是令我自覺罪孽深重！ 50年來的人生舞台，在蘇家的心目中，妳絕對是一位成功的老婆與母親，蘇家實在虧欠妳太多，妳常說「沒有功勞，也有苦勞」，實在太謙虛了！但是在妳的心目中，我卻是一位失敗的老公與父親，實在名符其實！每次看到孟宗與孟斌如何盡心盡力陪同孩子成長的照片，真是讓我感到羞愧萬分！ARTHER 好幾次想推薦我參加高雄市模範父親選拔，都被我婉拒，因為我尚有自知之明！ 夫妻吵架，無論誰是誰非，「太太永遠沒有錯」。50年的婚姻生活，由於我的火爆脾氣，導致我們有數不盡的爭吵與冷戰，每次爭吵對妳而言，又是傷心往事的再次湧現，不堪回味，非常感謝妳的包容與諒解，否則我們早已緣盡各奔前程！ 雖然妳偶而會表達你的心聲與無奈：「嫁給妳是錯誤的選擇」，但是你別忘了我們是經過漫長7年的愛情長跑，始決定共同永浴愛河，怎麼能夠輕言悔不當初？。俗語說：「百年修得同船渡，千年修得共枕眠。」難道我們不該珍惜此輩子的姻緣嗎？我們無法預測還有多少晚年餘生，千言萬語，盡在不言中，讓我誠心回饋妳對蘇家犧牲奉獻於萬一，陪妳共同走完人生的最後旅程。 永遠愛你的老公

孟宗： 爸媽非常感謝你們全家南下高雄將近一個星期，所給予三代同堂的天倫之樂！其實，為享受難得的天倫之樂，八月二十三日及二十四日兩天前往台北參加修法會議都藉故請假；事務所工作也幾乎休假。但是昨晚在夢時代親眼目睹你不當體罰奕昌事件，頓時感到非常心痛，情不自禁掉下幾顆眼淚。昨晚爸爸立即自我反省： 也許爸爸以前曾經不當體罰你們三兄弟，造成現在你報復在孫子身上。果係如此，那麼爸爸實在太對不起奕昌了。爸爸寧願相信這事件僅是你情緒失控的無心之過。 如果時光可以倒流，我將要採取下列方法管教孩子： 永遠放棄體罰！如果孩子在父母面前犯錯，儘量不要當場立即處理，以避免情緒失控的無心之過。最佳方式為事後與孩子溝通。讓孩童知道犯錯之原因何在，如有處罰之必要，儘量鼓勵孩子自行處罰。　 奕昌與奕承都是聰明又可愛的孩子，爸媽相信奕昌已有相互溝通的能力，培養孩子與父母相互溝通的能力，也是訓練孩子建立良本好人際關係的基礎。 再次聲明爸媽無權干涉你管教孩子，祇想讓你知道爸媽的心聲而已。 「父母的態度決定孩子的高度」這是一本值得為人父母應該閱讀的好書。 非常感謝你為爸爸購買最新型筆記型電腦及其他設備。 爸爸

親愛的家人們, 接手新工作已進入第三週了. 這新工作中有許多事情是我在踏入社會工作了十七年都沒有經歷過的, 也因此我還在調適學習當中. 在我走馬上任的第一個星期裡, 我就開始體驗了所謂的便當文化, 跟政府機關與我自己的單位有開不完的會議, 也因此這一週來我吃到的便當總數超過了這一年來的數量. 在第二週, 我體驗到政府所編列的預算有多可觀, 即使我自己的單位是個非營利機構~ 我可以選擇拿折舊津貼開我自己的車, 這津貼相當於一個社會新鮮人的月薪, 以及可觀的油錢補貼 (這優沃的補貼讓我超想捨95汽油改加98的!), 我也可以選擇開他們那一年新的公務車, 如此一來我也就不用負擔車子保險或維修費用! 但其實不論我選擇哪一個, 我其實都沒什麼機會自己開車, 因為只要我要外出開會, 單位都一定會租有車子/司機接送~ 我一開始是選擇了開自己的車拿津貼, 不過現在我打算改選第二選項, 既省麻煩也省錢! 上任後單位有來詢問我想使用哪一款手提電腦, 由於單位並沒有什麼針對選用電腦品牌的特定規章, 我便要了一台SONY製的, 他們給我的還是此品牌的頂級款! 接下來他們又問我想要什麼樣的手機, 一開始我覺得我的第一代iPhone已經夠用所以回絕了, 不過我們電子工程部的人來問我為什麼我不用傳輸速度更快的3G iPhone, 反正單位也是准許的! 因此, 我在今天拿到了我的新手機 (舊的那款我就請惠娟代用囉…) 然後在今天我發現了我那間比我舊家還大的宿舍的租金是單位以”工程計劃”的名義所支付, 這還包括了裡頭的電話帳單與電視/電影節目隨選功能的費用 現在來到了上任後的第三個禮拜, 我幾乎是為了眾多的會議而天天台北新竹來回跑~ 也因此讓我覺得要決定住在新竹或台北實在是一個不太容易的事, 因為不論住在哪一個城市都似乎沒法為我節省太多舟車勞頓時間… 雖說這許許多多的會議都有一堆的智囊團參與, 但似乎都不常能馬上有決議. 我對於會議裡所討論的議題所涉及的重要性也深感驚悸! 我第一個與政府單位開會的主題是要討論如何幫日益萎頓的台灣服務業振興轉型~ 第二場會議則是為了要尋求解決台灣愈來愈高的失業率. 第三場是研討如何幫助SME產業. 其實這些議題在不久之前都還是我拿來評論檢視政府的議題, 而今我的角色不一樣了, 我得要跟政府站在同一陣線一起打拼. 另外, 我得要儘快決定如何把一大筆(想都想不到的大數目) 在今年提撥給我們的預算在年底前消化掉, 否則這筆預算就得歸還給政府, 而這是會讓那些編列預算的人被責怪沒能精準一些的… 說了這麼多, 我只是想跟你們分享, 這工作是我在離開上一個工作的前三天確定拿到的. 在這之前我持續不斷地向上帝禱告, 也深信神會帶領我. 等待確實是漫長的, 也累了身邊關心我的人比我還焦慮我的未來… 不過這也因此是一個很好的見證, 神像是關上了幾扇門來測試我對祂的信心! 當工研院為我的接任舉行記者會, 很多人都因此或打電話或寫電子信件給我, 或在網路上討論著. 許多人都對於我的接任抱著很高的期許, 他們相信我能為政府為台灣經濟帶來正面的影響! 姑且不論他們是不是對我期望過高, 我接下了這份委任. 我也約略地被過來人們提醒別對於跟政府合作有太多的期待, 老實說在接任以來的短短三週裡我也略有體認. 然而, 我對自己有小小的期許, 若說有十個由智庫提出來的提議方案會被政府的官僚作風與低效率給糟蹋掉了, 我希望自己能至少讓其中一項被真正有效地正面落實. 雖然這樣低的”打擊率”極不符合美國職棒大聯盟的標準, 但請相信我, 這已經能為現今的就業市場做大幅的提升! 無論我在這個工作崗位上一年或者三年, 我都一定不會在此退休. 而在我離開之前, 或在我被這工作所享有的極大福利與權利寵壞之前, 就像我在本週跟兩百多位同事開會時所說, 也想拿來與你們分享的, 是: 我只希望能對些許事情有正面影響力, 也希望能因這工作交到更多朋友. 尤有甚者, 是期望你們持續地為我祈禱與小撇步分享並支持我在這裡所接受的任務. 總而言之, 祈求上帝保佑看顧我們這個國家! 台灣真的需要一些奇蹟來幫助我們重拾過去那種富強康樂的景象. -- Steve Faith, Hope, Love

我的心聲! 1978年中美斷交,我被迫辭去教師職位,含淚帶著三個小孩去美國唸書, 並留在美國照顧他們. 如今孩子大了, 各有自己的天下, 我卻失去了人人羨慕的18%, 如今想起, 後悔莫及, 如果人生能夠重來, 打死不幹, 雖然我現在過著還可以的生活, 但覺得一生最大的遺憾莫過於此. MY REGRET In 1978, the United States of America broke off diplomatic relations with Taiwan.It caused many people to leave Taiwan and go to America or other countries for the reason of safety. In 1980, my husband and I decided to send our three kids to America to continue their education. But I had to give up my teaching job in Taiwan to take care of my sons in America, only just 5 years before applying retirement. Although my children all graduated at the top of ten famous universities in America, and have had much success in their jobs, at the same time,I enjoy my old age life of ease,I regret the above decision very much.Because it made me a great loss of enjoying life-time 18% interest on pension.To tell the truth,I still consider my moving to the Unites States in 1980 as the most regrettable decision of my life.If time could flow back as water did,I would have never done it again！

親愛的爸媽， 謝謝您們這兩週對Kevin的照顧，相信他未來在他的人生當中，這一個短暫的相處會有許多回憶和啓發。 有一件事之前Kevin有轉告我，但是我忘了提起，就是爸說當初我選擇去柏克萊大學而不去加州理工學院，是因爲學費的原因，以及之後成為基督徒是因為公立學校較辛苦的原因。我當下聽了覺得非常訝異，不知道這樣的誤解已經在爸心中多年了。其實，當初選擇學校時，就已經知道爸媽會全力支持，所以在參觀加州理工學院之後，就覺得校園內感受到學術氣氛濃厚，幾乎見不到人在小小的校園中閒聊，因此後來柏克萊後補進去後，連到校園參訪都沒有就決定要去一個比較多元化的學校。之後在選研究所時，對加州理工學院又有多一些了解，並在所有選擇中，又是排名最高，又有助教獎學金，於是又選了加州理工學院，只不過第一年就交上兩位只來唸碩士的朋友，後來博士不唸就決定到業界去了。只能夠說是人生有時決定還是會走到意想不到的路徑，甚至走回之前不想走的路。 至於成為基督徒之事，是因為高中就只參加過兩次團契，到了大一跟了幾位教友固定每週參加團契和主日，雖然大一是我四年唸書最花時間及成績最好的時候，可是我大一暑假決定成為基督徒，因為觀察及體驗了一整年，這樣的信仰及各種以後的歷練，反而比我在專業上的學習，更能幫助我在人生上的處事和歷練。 在此還是謝謝爸媽從小對我的栽培，包含送我們到美國唸書兩地相隔的辛勞、在金錢上不用煩惱、在信仰上尊重我的決定，若是我們對我們小孩的教育和照顧有達到任何百分比，一切都是您們先以身作則的原因。 愛您們！ 孟宗

Congrats and Course Selection Stephen Su 2019年3月12日 上午8:37 寄給 22kevins、 Hui-Chuan、 我 Hi Kevin, Glad to hear that you have got in Honors Spanish and Honors English, plus Trombone Wind Ensemble. Your effort is well rewarded despite we wish you have spent less time in playing games. But your potential and achievement are well above where I was at your age. Only difference was that I worked a bit harder due to having to learn English as a second language when arriving at US to start 9th grade in second semester. I basically did not start on core courses until 10th grade first semester. Thanks God I was able to be admitted to Caltech and wait listed in to Berkeley which I accepted later. For your next year, either AP computer engineering or AP Physics should be fine by your choice. Do not be afraid take take on a higher challenge if it means tougher grade. Your potential is limited if you do not give it a try with your best. But most importantly give it all out while enjoying the learning process regardless of outcome. Congrats again! Stephen

2021/10/5 Dear Kevin, To tell the truth ,Grandma and I are very proud of your father, uncle Jack and Danny because they all graduated from the top ten ranking universities of the United States and their successful life career besides. You are going to apply for admission to colleges right now. Grandma and I are very concern about what kind of occupations you will choose as your life career. Frankly speaking, I had a surprise for your plan on studying military academy during this early year. I am so glad that you have changed your mind for major switching to go for medical career recently. It’s good news that you will be a second doctor in SU Family because medical career has a noble aim for treating the disease to save the patient. I appreciate your thinking to do anything by self- determination. But as you know that to get admission to medical college is not very easy. So how to make the list of College Applications seems to be a matter of great importance. Uncle Jack is very concern about your list of College Applications. The attachment is Uncle Jack’s Curriculum Vitae. There is an old saying in Chinese ‘’Two heads are better than one.”（三個臭皮匠勝過一個諸葛亮）May I suggest your father to arrange you to talk to uncle Jack.? I am convinced that you will carefully reconsider the list of College Application after you talk to uncle Jack. Don’t let the chance slip by. I look forward to seeing your respond to my suggestion. Sincerely yours Grandpa l 2021/10/10 Dear Kevin, I am very glad to hear that you have talked to uncle Jack last night. Thank you for responding my suggestion so quickly. Grandpa 2021/10/10 Dear Kevin, You are old enough to understand the meaning of destiny. For example, you and I have the relationship of grandson and grandpa in SU family. It’s predestined affinity. I have been cherished our relationship very much. And you? 2021/10/11 Dear Kevin, I would like to discuss concepts of education investment with you. Do you like to talk in English or Chinese? Grandpa

蘇吉雄 2017年8月22日 上午9:53 寄給 Stephen、 Danny Dear Danny, It's nice to hear you have a short business trip to Taipei, but we are very sorry for missing the chance to see you on September 8. We'll be taking a group trip to Japan on September 15 through September 20. So far Dad have two important cases to be done before taking trip to Japan. Anyway, may you have a nice short trip. Dad & Mom 2016年5月6日 上午10:55 Frankly speaking, I had a negative prediction when I got the news that Alvin had to be interviewed twice. I am very concerned with Alvin's feeling after he got the bad news. We have to inspire him with courage for the first time of frustration. May we apply for Alvin's the records of Exam scores in order to review his weakness. 2015年11月30日 下午10:02 寄給 stephen、 張惠娟、 Jack、 Sabrina、 Ya-chi、 Danny Dear family: Dad & Mom were very grateful for the 50-year wedding anniversary dinner and gift what you did. Please see the attachment that I wrote Mom during the 50-year wedding anniversary, just keep it as memory, but do not publish it. Dad

Dear Dad and Mom, We're all very grateful for all the sacrifices that you and mom made to bring us to America. For whatever it's worth, I always keep those sacrifices mind as I tried to be a parent, and hopefully some of what you taught us will rob off onto Adrian and Albert. Danny 2015/12/1

Stephen, There were two benefactors for our family to get permanent resident qualification of the U.S. So far they have been still lived in L.A. They have come back to Kaohsiung to visit Dad & Mom for many times. Aunti got good grades in primary school, but she has been forced to interrupted her advanced education after finishing primary education for undertaking responsibility of housework due to poverty in the family and Grandfather's ideology for valuing males and belittle females. As eldest son in the family, I regretted very much that I couldn't help Aunti pursuing advanced education. Indeed, we are getting older by the day,I should be going to L.A to visit Aunti and the two benefactors, but I have promised that Mom & I will participate in wedding ceremony of the two benefactors' son/daughter in L. A.if our health are OK. Then we could visit Aunti conveniently. So, Mom & I have decided not to go to L.A this year. Dad 2018/7/20